Mesenchymal Stem Cell Allograft in a Nonunion Fibular Fracture: A Case Report

Brett D Sachs and Kaitlyn Bernhard

Departemnt of Podiatric Surgery, Presbyterian St. Luke’s Medical Center, USA
Deprtment of Podiatric Medicine and Surgery, Presbyterian St. Luke’s Medical Center, USA

^*Correspondance to: Brett D Sachs 

 PDF  Full Text DOI: 10.25107/2474-1647.1395

Abstract

Ankle fractures are common injuries treated by the foot and ankle surgeon. The majority of stable, uncomplicated, minimally or non-displaced distal fibular fractures will heal with adequate immobilization and conservative treatment. However, some patients will develop a symptomatic partial union or nonunion. Several factors can contribute to a nonunion following a fracture including smoking, obesity, infection, and diabetes mellitus. In cases of surgical reconstruction, augmentation with osteobiologics consisting of mesenchymal stem cells can be utilized to enhance osseous healing of the nonunion site. We present a successful case of a distal fibular nonunion repair with the use of a partially demineralized allograft bone combined with adipose derived mesenchymal stem cells to promote bone healing. At six months follow-up, there was solid bone healing of the fibular nonunion with complete resolution of symptoms.

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Cite the article

Sachs BD, Bernhard K. Mesenchymal Stem Cell Allograft in a Nonunion Fibular Fracture: A Case Report. Clin Surg. 2017; 2: 1395.