Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Vascular Surgery
  •  Thoracic Surgery
  •  Otolaryngology - Head and Neck Surgery
  •  Neurological Surgery
  •  Gynecological Surgery
  •  Colon and Rectal Surgery
  •  Oral and Maxillofacial Surgery
  •  Cardiovascular Surgery

Abstract

Citation: Clin Surg. 2017;2(1):1352.Review Article | Open Access

Combined Liver Kidney Transplantation in Pediatrics: Indications, Special Considerations, and Outcomes

David Cha, Katherine Concepcion, Amy Gallo and Waldo Concepcion

Department of Multi Organ Transplantation, Stanford University School of Medicine, USA
Department of Surgery, Loma Linda University School of Medicine, USA

*Correspondance to: Waldo Concepcion 

 PDF  Full Text DOI: 10.25107/2474-1647.1352

Abstract

Combined liver and kidney transplants (CLKTs) are not commonly performed in pediatric patients. Advancing the medical community’s understanding of when these procedures may be the optimal choice for pediatric patients and when other options may be preferable is crucial. There are three main pediatric groups who may be considered candidates for CLKT: (1) those who suffer a disease that leads to irreversible liver and kidney damage‒including autosomal recessive polycystic kidney disease; (2) those with end-stage renal disease caused by a liver-based metabolic disease‒ including primary hyperoxaluria types 1 and 2, methylmalonic acidemia, and atypical hemolytic uremic syndrome; and (3) those who present with concomitant liver and kidney failure‒including patients with Boichis syndrome (nephronophthisis plus congenital hepatic fibrosis) or with liver tumor plus nephrotoxicity. We review here the indications and special considerations related to CLKT for patients in each of these groups and the outcomes seen to date in these pediatric patient groups. With the appropriate donor selection, family education, and medical team commitment CLKT has been shown to be and, we believe, will continue to be an outstanding option for medical management in this select group of patients. Continued advances pre-transplant, intra-operatively and post-transplant will be required to optimize success.

Keywords

Combined liver kidney transplantation; Simultaneous liver kidney transplantation; Autosomal recessive polycystic kidney disease; Primary hyperoxaluria, methylmalonic acidemia; Atypical hemolytic uremic syndrome; Boichis syndrome, Concomitant liver and kidney failure

Cite the article

Cha D, Concepcion K, Gallo A, Concepcion W. Combined Liver Kidney Transplantation in Pediatrics: Indications, Special Considerations, and Outcomes. Clin Surg. 2017; 2: 1352.

Search Our Journal

Journal Indexed In

Articles in PubMed

Monitoring an Ongoing Enhanced Recovery after Surgery (ERAS) Program: Adherence Improves Clinical Outcomes in a Comparison of Three Thousand Colorectal Cases
 PubMed  PMC  PDF  Full Text
Automated Sagittal Craniosynostosis Classification from CT Images Using Transfer Learning
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

Prevalence and Clinical Characteristics of Autoimmune Gastritis in Patients with Severe Atrophic Gastritis
 Abstract  PDF  Full Text
sefulness of Magnetic Resonance Imaging/Ultrasound Fusion Imaging and Intraoperative Magnetic Resonance Imaging for Malignant Soft Tissue Tumor: A Case Report
 Abstract  PDF  Full Text
View More...