
Major Scope
- Colon and Rectal Surgery
- General Surgery
- Gynecologic Oncology
- Plastic Surgery
- Neurological Surgery
- Orthopaedic Surgery
- Orthopaedic Surgery of the Spine
- Neonatal Surgery
- Prenatal Surgery
- Trauma Surgery
- Surgical Intensivists, Specializing In Critical Care Patients
- Thoracic Surgery
- Congenital Cardiac Surgery
- Thoracic Surgery-Integrated
- Vascular Surgery
Abstract
Citation: Clin Surg. 2016;1(1):1258.Review Article | Open Access
Impact of Skeletal Muscle Loss and Functional Deconditioning on Outcomes in Hepatic Resection and Liver Transplantation: A Review
Randeep Kashyap and M. Katherine Dokus
Department of Surgery, Division of Solid Organ Transplantation, University of Rochester Medical Center, USA
*Correspondance to: Randeep Kashyap
PDF Full Text DOI: 10.25107/2474-1647.1258
Abstract
A growing number of older and sicker patients are being offered surgical intervention for their ailments. The effects of frailty and sarcopenia, syndromes characterized by loss of muscle mass and functional reserve are more prevalent in this population, and operative outcomes are just beginning to be elucidated. Here, we provide a review of published reports on mortality, morbidity and resource utilization in liver transplant and hepatectomy on frail and/or sarcopenic adults. Fourteen studies were selected for review; 82% of analyses reporting described greater resource utilization (e.g. length of stay, readmissions) in the frail cohort, 80% demonstrated increased rates of morbidity. The majority of included studies (69%) reported higher mortality in the debilitated groups undergoing liver transplant or hepatectomy with hazard of death ranging from 1.05-26.4. Though the preponderance of studies pointed to worse outcomes for frail or sarcopenic patients; lack of uniformity on the operational definition of these concepts makes generalization and clinical application difficult. A validated, practicable measure can help surgical teams identify candidates at greater risk of poor outcomes and implement interventions to reduce such hazards.
Keywords
Frail; Sarcopenia; Liver transplantation; Liver surgery; Outcomes
Cite the article
Kashyap R, Katherine Dokus M. Impact of Skeletal Muscle Loss and Functional Deconditioning on Outcomes in Hepatic Resection and Liver Transplantation: A Review. Clin Surg. 2016; 1: 125.
Journal Basic Info
- Impact Factor: 2.395**
- H-Index: 8
- ISSN: 2474-1647
- DOI: 10.25107/2474-1647
- NLM ID: 101702548