Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Plastic Surgery
  •  Pediatric Surgery
  •  Gynecological Surgery
  •  Minimally Invasive Surgery
  •  Otolaryngology - Head and Neck Surgery
  •  Surgical Oncology
  •  Breast Surgery
  •  Cardiovascular Surgery


Citation: Clin Surg. 2016;1(1):1101.Research Article | Open Access

Contribution to Revascularization by Reciprocal Random Skin Flaps

Li Song, Xiu-Fa Tang, Ping Ji, Li-Na Gao, Xian-Ming Mo, Yong Li, Zhao H-W, Zhang F-G and Xiang X-R

Chongqing key Laboratory for Oral Diseases and Biomedical Sciences, Huazhong University of Science and Technology, China
Department of Periodontology, Chongqing Medical University, China
Department of Head and Neck Carcinoma, Sichuan University, China
Department of Oral and Maxillofacial Surgery, Chongqing Medical University, China
Laboratory of Stem Cell Biology, Sichuan University, China

*Correspondance to: Fu-Gui Zhang 

 PDF  Full Text DOI: 10.25107/2474-1647.1101


Background: The introduction of random skin flaps to plastic surgery has a major impact on wound closure and the reconstruction of normal and functional anatomical features, but the role of random skin flaps and the interactions between random skin flaps and recipients during random skin flap revascularization process remain to be fully elucidated.Methods: The authors endeavored to establish a reciprocal random skin flap model between green fluorescent protein (GFP)-transgenic and wild-type (wt) C57BL/6 mice. Blood vessel origination, growth directions and anastomosis positions were detected by a multitude of detective methods at postoperative days 3, 7, 14 and 21.Results: The results indicated that the reciprocal random skin flap model was successfully established between the two different mice; blood vessels originated from GFP-transgenic recipients grew into wt flaps, while blood vessels from GFP-transgenic flaps grew into wt recipients as early as day 3. It was promising and crucial to unveil vascular anastomoses between donor and recipient vascular networks occurring as early as day 3. Green fluorescent cell clusters increasingly augmented with significant differences among days 3, 7, and 14 (P < 0.05), but neither between days 14 and 21 (P >0.05), nor between two separate vascular networks at each time point.Conclusion: The authors harbored the idea that the random skin flaps played essential roles in promoting survival and were of vital significance to the ordered process of random skin flap revascularization by the outgrowth and by the ingrowths of capillary buds of skin flaps through a unique reciprocal random skin flap model.


Transgenic mice; Random skin flap; Revascularization; Physiological mechanism; Therapeutic angiogenesis

Cite the article

Song L, Tang X-F, Ji P, Gao L-N, Mo X-M, Li Y, et al. Contribution to Revascularization by Reciprocal Random Skin Flaps. Clin Surg. 2016; 1: 1101.

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