Journal Basic Info
- Impact Factor: 1.995**
- H-Index: 8
- ISSN: 2474-1647
- DOI: 10.25107/2474-1647
Major Scope
- Breast Surgery
- Colon and Rectal Surgery
- Orthopaedic Surgery
- Oral and Maxillofacial Surgery
- Thoracic Surgery
- Urology
- Gynecological Surgery
- Cardiovascular Surgery
Abstract
Citation: Clin Surg. 2016;1(1):1067.Research Article | Open Access
The Role of Prophylactic Lymph Node Dissection in Patients with Intrahepatic Cholangiocarcinoma
Satoh D, Matsukawa H, Araki H and Shiozaki S
Department of Gastroenterological Surgery, Hiroshima City Hiroshima Citizens Hospital, Japan
*Correspondance to: Daisuke Satoh
PDF Full Text DOI: 10.25107/2474-1647.1067
Abstract
Purpose: We investigated the role of prophylactic lymph node dissection (LND) in patients with intrahepatic cholangiocarcinoma (ICC).Methods: A retrospective analysis was performed evaluating the impact on survival of prophylactic LND and preoperative risk factors for histological lymph node metastasis (LNM) in a cohort of 49 patients with ICC of the mass-forming type, who underwent curative resection between 1995 and 2013.Results: There were no differences in both disease-free survival (DFS) and overall survival (OS) between the patients without LND and the patients with LND who did not have LNM. Multivariate analysis revealed that serum CA19-9 level >150 U/mL and LN size >5 mm on preoperative computed tomography (CT) were the significant preoperative risk factors for LNM. None of the patients with LN size <5 mm on preoperative CT and serum CA19-9 level ≤150 U/mL had LNM.Conclusions: Prophylactic LND did not significantly improve DFS or OS in the present study. Regional LND could be omitted for patients with LN size <5 mm in preoperative CT and serum CA19-9 level ≤150 U/mL who are unlikely to have LNM.
Keywords
Intrahepatic cholangiocarcinoma; Prophylactic lymph node dissection; Lymph node size; Serum CA 19-9 level
Cite the article
Satoh D, Matsukawa H, Araki H, Shiozaki S. The Role of Prophylactic Lymph Node Dissection in Patients with Intrahepatic Cholangiocarcinoma. Clin Surg. 2016; 1: 1067.