Case Report
Unidirectional Barbed Sutures can be used Safely in Pediatric Gastro-Intestinal Surgery
Erin Kloos*, Ravindra Vegunta* and Kristina Morgan*
Department of Surgery, Banner University Medical Center, USA
*Corresponding author: Erin Kloos, Department of Surgery, Banner University Medical Center, Phoenix 1111 E, McDowell Road Phoenix, AZ 85013, USA
Published: 10 May, 2017
Cite this article as: Kloos E, Vegunta R, Morgan K.
Unidirectional Barbed Sutures can
be used Safely in Pediatric Gastro-
Intestinal Surgery. Clin Surg. 2017; 2:
1469.
Abstract
Background: Since the sterilization of catgut in 1907, the essential structure of surgical suture has
not been modified beyond the evolution of synthetic and blended sutures from that of a simple
thread and needle until recently. First approved in 2007 for approximation of soft tissue, barbed
sutures (BS) are specially engineered sutures that slide through tissue in only one direction. These
sutures stay in position once placed without need for knots at each end and without need for
maintaining tension during placement. To date, there are no publications that document the use of
barbed sutures in gastrointestinal (GI) surgery in children. Our report consists of a short series of
cases demonstrating that the use of barbed sutures in laparoscopic GI procedures in children is safe.
Methods: A retrospective chart review was performed for the four children in whom unidirectional
BS – V-Loc (Medtronic, Minneapolis, MN, USA), was used for GI application, between January
01, 2013 and December 31, 2014. Variables including patient age and gender, duration of surgery
and specific suture used as well as time to feeds post-operative length of stay, post-operative
complications were evaluated.
Results: All procedures were completed without adverse events and without subsequent
complications including wound infection and readmission for wound dehiscence or anastomosis
breakdown.
Conclusions: We conclude that the use of V-Loc absorbable unidirectional barbed sutures in
laparoscopic gastrointestinal anastomosis is feasible and safe in children including neonates.
Keywords: Barbed sutures; Pediatric surgery; Gastro-intestinal surgery
Introduction
Since the sterilization of catgut in 1907, though suture materials have evolved greatly to include
synthetic materials and antibacterial impregnated sutures, their essential structure has not been
modified from that of a simple thread and needle. First patented in 1964 by John Alcamo, though
not approved for use in the United States until 2007 for approximation of soft tissue [1], barbed
sutures (BS) are specially engineered sutures that slide through tissue in only one direction.
BSs, unlike standard monofilament or braided sutures, are constructed to have small quills
evenly dispersed along the length of the suture and thus stay in position once placed, without the
need for maintaining or readjusting tension. In addition, no knots need to be tied in order to secure
the suture in place. This allows surgeons to complete an intestinal anastomosis in less time and
when used during minimally invasive surgery, potentially save the patient one trocar site that would
otherwise be used to maintain tension or secure knots.
In spite of the evidence of their potential benefits, BSs have only been used sparingly in children.
To date, there are no publications that document the use of BSs in gastrointestinal surgery in children.
This report consists of a short series of cases demonstrating that the use of BSs in laparoscopic GI
procedures in children is safe.
Methods
We obtained IRB approval and performed a retrospective chart review on four children in whom unidirectional BS, V-Loc 90 (Medtronic, Minneapolis, MN, USA) was used for GI application between January 01, 2013 and December 31, 2014. Variables including patient age and gender, duration of surgery and specific suture used as well as time to feeds post-operative length of stay, post-operative complications were analyzed.
Table 1
Results
The first patient was a 12-year-old boy who underwent excision of a gastric leiomyoma followed by repair of the gastrotomy using BS. Two patients were neonates with duodenal atresia. They underwent laparoscopic duodenoduodenostomy at two days of age using BS for the anastomosis. The fourth patient underwent laparoscopic duodenojejunostomy using BS for distal duodenal stenosis at seven months of age. All anastomoses were single-layer and laparoscopically hand-sewn. All procedures were completed without adverse events and without subsequent complications involving the anastomoses (Table 1).
Discussion
Laparoscopic surgery is expected to result in less postoperative
pain and shorten hospital stay when compared to open surgery.
While surgeons’ skills have advanced since the standardization of
laparoscopic procedures, some maneuvers still prove to be universally
more challenging when performed laparoscopically. BSs have the
potential to make anastomosis faster and safer for the patient as well as
reproducible among surgeons. Historically, while there are a limited
number of publications on intra-abdominal use of BSs in adults, most
studies have focused on skin and fascia closure using BSs.
V-loc suture, used in all cases reported in this paper, is made
from an absorbable copolymer polyglyconate which has the same
degradation properties as a similar synthetic monofilament absorbable
suture. The BS is created by etching quills into the polymer in a helical
pattern around the strand. The barbs then act as individual anchors
in the tissue that grasp the collagen fibers securing the suture in place
as it passes through tissue (Figure 1). As the barbs inherently decrease
the diameter of the suture, they are sized according to their core
diameter 3-0 V-loc suture will have the same tensile strength as a 3-0
Maxon suture. The first two centimeters of the suture lacks barbs as to
make it repositionable up to this point. The end is fitted with a loop to
secure the first throw. The final throw can be secured without a knot
with only a j-loop or a few throws beyond the incision, as the barbs
will hold the suture in place. The suture will completely resorb in 180
days; tissue closure strength is approximately 50% at 30 days [2].
BSs not only have the potential to simplify surgical technique
and eliminate the risk of knot failure, but may also be an inherently
superior design of engineering. While the barb cut into the suture does
reduce the core diameter of the suture and thus its tensile strength,
in vivo studies in animal of closure of dermal and abdominal wall
showed same wound security with BSs as with conventional sutures
that are 1 size smaller. Needles of a smaller diameter than the suture
itself create tunnel in the tissue through with the barbs can then
secure themselves in the surrounding collagen. This thus reduces the
need for a tight approximation which may lead to local ischemia and
potential wound necrosis [3].
More importantly perhaps, research shows that even in the hands
of an experienced laparoscopic surgeon, intracorporeal knots will fail
up to 50% of the time. In 2005, Ritter et al. [4] published a study in
which 48 knots of 100 tied by extensively trained minimally invasive
surgeons slipped when placed in a tensiometer prior to the suture
(2-0 silk) breaking.
As canine and human intestines are similar in size and histology,
canine models have been used to test the utility of BSs. Omotosho et
al. [5] looked at the use of BS in 24 dogs to close enterotomies in the
stomach, jejunum and colon. Three enterotomies were made and each
closed with monofilament, absorbable BS and nonabsorbable suture
respectively in a single-layer simple running fashion. The closures
were then tested at day 3, 10 and 21 to evaluate for leak and burst
pressure. No significant difference was found between the control and
BS groups for leak rates, overall 0%, but the enterotomies were able to
be sutured closed 35% to 42% faster [5].
Ehrhart et al. [6] also tested BSs in the canine model 14 dogs
underwent laparoscopic gastrotomies and enterotomies of the
jejunum and colon. Similar to the aforementioned study, the defects
were closed with both monofilament with three square knots at each
end, and 3-0 V-loc BSs then burst pressures were tested at day 3, 7 and
14. Again, there was no significant difference in the leak rate between
monofilament but the closure rate with BSs was again significantly
more efficient [6].
Two studies by Tyner et al. [7] and Lee et al. [2] have evaluated
BS anastomosis in human models. Tyner studied 84 morbidly obese
patients who underwent laparoscopic gastric bypass surgery with a
hand-sewn gastrojejunostomy anastomosis and hand-sewn closure
of the common enterotomy of the jejunojejunosomty. In all, 84
cases were studied, 46 of which were with 3-0 V-Loc 180 BS and 38
with traditional 3-0 PDS. As with the animal models, there was no
significant difference in overall complication rate (no incidences of
anastomotic leak or stenosis for each group). In addition the cases
with BS were completed on average 23 minutes faster [7].
Lee et al. [2] studied the use of BSs in laparoscopic gastrectomy
for tumor resection in which staple anastomosis entry holes were
closed using knotless unidirectional BS in a continuous two-layer
fashion. Two hundred forty two patients underwent a total of 256
intracorporeal anastomoses all with the use of the 3-0 V-Loc suture.
The researchers determined that though this was a novel technique
for most of the surgeons in the study, all mastered the suture by 6
cases. At the conclusion of this study, there were no deaths and no
incidence of anastomotic leak, bleeding or stricture. In conclusion,
the researchers determined that intracorporeal suturing is a safe practice in gastric surgery though further research still needs to be
conducted [2].
In our study population, though small, we too had no
complications when using BSs.
Figure 1
Conclusion
The authors of this study conclude that the use of V-Loc absorbable unidirectional BSs in laparoscopic gastrointestinal anastomosis is feasible and safe in children including neonates. In addition, their use may be superior to that of traditional suture; at the minimum, BS can reduce operative time with no adverse consequences, though further investigation is needed in this population.
References
- Ruff GL. The history of barbed sutures. Aesthet Surg J. 2013; 33: 12S-16S.
- Lee S, Kawai M, Tashiro K, Nomura E, Tokuhara T, Kawashima S, et al. Laparoscopic gastrointestinal anastomoses using knotless barbed absorbable sutures are safe and reproducible: a single-center experience with 242 patients. Jpn J Clin Oncol. 2016: 46: 329-325.
- Paul MD. Bidirectional barbed sutures for wound closure: evolution and applications. J Am Col Certif Wound Spec. 2009; 1: 51-57.
- Ritter E, McClusky D, Gallagher A, Smith C. Real-time objective assessment of knot quality with a portable tensionmeter is superior to execution time for assessment of laparoscopic knot-tying performance. Surg Innov. 2005; 12: 233-237.
- Omotosho P, Yurcisin B, Ceppa E, Miller J, Kirsch D, Portenier D. In vivo assessment of an absorbable and nonabsorbable knotless BS for laparoscopic single-layer enterotomy closure: a clinical and biomechanical comparison against nonBS. J laparoendosc Adv Surg Tech A. 2011; 21: 893-897.
- Ehrhart NP, Kaminskaya K, Miller JA, Zaruby JF. In vivo assessment of absorbable knotless barbed suture for single layer gastrotomy and enterotomy closure. Vet Surg. 2013; 42: 210-216.
- Tyner, RP, Clifton GT, Fenton SJ. Hand-sewn gastrojejunostomy using knotless unidirectional barbed absorbable suture during laparoscopic gastric bypass. Surg Endosc. 2013; 27: 1360-1366.