Study on the Effect of Dexmedetomidine Combined with Sufentanil in Post-Operative Epidural Analgesia after Cesarean Section

Yin Li-Xin*

Department of General Surgery, Chinese Academy of Science, China

^*Correspondance to: Yin Li-Xin 

 PDF  Full Text DOI: 10.25107/2474-1647.3395

Abstract

Objective: The aim was to provide a reliable trial of the application of sufentanil combined with dexmedetomidine for epidural analgesia after cesarean section in terms of clinical efficacy and safety. Methods: The study population was selected from 80 cases of primiparous women who underwent elective caesarean section in Jiangyin People's Hospital from March 2019 to March 2021, and they were equally divided into two groups, with 40 cases in each group. In the control group (Group C), sufentanil citrate 50 ug + 0.9% saline, 120 ml in total; in the study group (Group D), sufentanil citrate 50 ug + dexmedetomidine hydrochloride 1 ug/kg + 0.9% saline, 120 ml in total. Observation indexes: VAS analgesia scores for contraction pain and incisional pain and OAA/S modified sedation scores in the two groups of pregnant women after surgery; determination of the time to first lactation in both groups; adverse events during postoperative analgesia. Results: The control group had significantly higher VAS scores for incisional pain and contraction pain at 4 h, 8 h, 12 h and 24 h postoperatively than the study group (P<0.05); the control group had significantly higher OAA/S scores for sedation at 4 h, 8 h, 12 h and 24 h postoperatively than the study group (P<0.05); the study group had less time to first lactation than the control group (P<0.05). In terms of time to first lactation, the study group had less time than the control group (P<0.05); in terms of lactogen levels at 24 h and 48 h postoperatively, the study group had significantly higher levels than the control group (P<0.05); in terms of adrenocorticotropic hormone levels at 24 h postoperatively, the study group had significantly lower levels than the control group (P<0.05); in terms of prostaglandin hormone levels at 24 h postoperatively, the study group had significantly lower levels than the control group (P<0.05); in terms of maternal adverse effects in both groups, the control group had significantly higher levels of nausea and vomiting. The number of nausea and vomiting in the control group was significantly higher than that in the study group (P<0.05). Conclusion: The combination of the two drugs for post-operative epidural analgesia after cesarean section is more effective in relieving maternal tension and anxiety without excessive sedation, with fewer adverse effects and reduced postoperative stress.

Keywords

Caesarean section; Dexmedetomidine; Sufentanil; Epidural analgesia

Cite the article

Li-Xin Y. Study on the Effect of Dexmedetomidine Combined with Sufentanil in Post-Operative Epidural Analgesia after Cesarean Section. Clin Surg. 2022; 7: 3395..