Ji-Hyun Kim1, Kyong-Hwa Jun2* and Hyung-Min Chin2
1Department of Surgery, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Republic of Korea
2Department of Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Republic of Korea
Background: To evaluate the prognostic value of tumor volume in gastric cancer, we assessed calculated Tumor Volume (cTV) based on pathologic reviews after gastrectomy and investigated its correlation with long-term outcomes of patients. Methods: In total, 574 gastric cancer patients who underwent curative gastrectomy were enrolled and divided into subgroups according to cTV: 0-160.0 for the cTV1 group, 160.1-468.0 for the cTV2 group, and ≥ 468.1 for the cTV3 group. Results: Among enrolled patients, 403 (70.2%) were in the cTV1 group, 116 (20.2%) were in the cTV2 group, and 55 (9.6%) were in the cTV3 group. The 5-year overall survival rate of cTV groups were significantly different: 94.4% in cTV1, 86.2% in cTV2, and 69.3% in cTV3. In the multivariate analysis, the cTV group was an independent prognostic factor for OS (HR 2.50, P=0.049) and DFS (HR 2.25, P=0.044). In the subgroup analysis, there was a significant difference according to the cTV group in both OS and DFS in T4 and N3 gastric cancers. Conclusion: The cTV showed a significant correlation with the prognosis of gastric cancer patients after surgery even in the same stage. Therefore, it might be used to stratify patients with poorer prognosis in advanced gastric cancer and to provide additional information on the patient's treatment strategies
Kim J-H, Jun K-H, Chin H-M. Prognostic Value of Calculated Tumor Volume in Patients with Gastric Cancer. Clin Surg. 2021; 6: 3373..