Sarah Tolleron1, Audrey Cartault1, Sofia Mouttalib2, Julie Vial3, Lea Gauthier3, Agnes Sartor4, Marion Groussolles4, Caroline Munzer5, Olivier Abbo2 and Catherine Pienkowski1*
1Endocrinology and Medical Gynecology Unit, Rare Gynecological Pathologies Reference Center, Children's
Hospital, University of Toulouse Hospital Center, France
2Visceral Surgery Unit, Children's Hospital, University of Toulouse Hospital Center, France
3Children's Hospital Medical Imaging Center, University of Toulouse Hospital Center, France
4Prenatal Screening Center, Hospital Paule De Viguier, France
5The Pediatric Clinical Research Unit, Children's Hospital, University of Toulouse Hospital Center, France
Objective: To evaluate the outcomes of puberty in girls followed for Fetal Ovarian Cysts (FOC). Design: We included 83 girls of eight and more, followed at Toulouse Hospital for FOC. Historical data were collected through computerized medical record. Recent clinical, US and hormonal data were collected through a questionnaire filled up by the patients and their parents. Results: Of 83 eligible patients, 51 agreed to participate. Their median age was 11.6 years [8.6-17.6], 37 patients (72.5%) had pubertal signs, 18 patients had menarche (36%). The median age of puberty onset was 11 years 95% CI (10.5-11.5) and that of first menstruation was 13 years 95% CI (12.2- 13.6). Fifty-two patients (96%) had no recurrence of ovarian cysts. No significant difference in the age of menarche, AMH levels, ovarian volume was noted. Regarding the 54 FOC including 3 bilateral cysts, 32 were simple (59.3%) and 22 (41%) were complex. The rate of cyst regression is 90% of cases in 2.1 months [0-8.9] for simple cysts and 54% of cases in 3.7 months [1.1-10.2] of complex cysts (rate p<0.0001 and time p=0.06). 23 small Cysts (diameter <40 mm) regressed in 90% of cases against 56% for the largest cysts (n=31) (p=0.01). The duration of regression of small cysts was 1.9 months, significantly less than that of largest cysts (median 3.4 months) punctured or not (p=0.05). Conclusion: The occurrence of FOC, whether liquid or complex, does not modify the pubertal profile, and no recurrence was observed.
Tolleron S, Cartault A, Mouttalib S, Vial J, Gauthier L, Sartor A, et al. Pubertal Evolutionary Profile of Children Monitored for Fetal Ovarian Cyst (FOC Study). Clin Surg. 2021; 6: 3356..