Hao Liu1, Shishi Qiao1, Xiaoyue Fan2, Minghao Dong3, Liangjie Feng1, Yufei Gu1, Yingxuan Zhang1 and Shuai Huang1*
1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, China
2Department of Pathology, The First Affiliated Hospital of Zhengzhou University, China
3Hepatobiliary Surgery of the Central Hospital of Sanmenxia Affiliated to Henan University of Science and Technology, China
Pancreatic Cancer (PC) is one of the human digestive malignant tumor which has a poor prognosis. Exospores, containing proteins, nucleic acids and enzymes, are a class of extracellular vehicles defined as 40 nm to 150 nm diameter membrane nanovesicles of endocytic origin. As we all know that exosomes work as potential diagnostic markers for pancreatic cancer. Exospores in cancer initiation and progression are currently unclear. Our study focuses on the mechanisms and functions of exosomes that can accelerate pancreatic cancer cell proliferation, migration, and invasion. This review highlights our understanding of the interaction between exosomes and the malignant biology of pancreatic cancer. And we will also discuss the possible clinical application of exosomes.
Liu H, Qiao S, Fan X, Dong M, Feng L, Gu Y, et al. The Role Exosomes Played on Pancreatic Cancer. Clin Surg. 2020; 5: 2910.