Tsutsumi S1*, Kobayashi K1, Yasui M1, Tatenuma T1, Noguchi G1, Osaka K1, Umemoto S1, Ito H2 and Kishida T1
1Department of Urology, Kanagawa Cancer Center, Japan
2Department of Thoracic Surgery, Kanagawa Cancer Center, Japan
Background: We investigate the effects of chemotherapy and surgical treatment on the extragonadal germ cell tumor of which poor prognosis has been reported. Methods: We analyzed the prognosis of 31 patients with extragonadal germ cell tumor treated at Kanagawa Cancer Center by factors including patient background, the condition of disease, and treatments. Result: As the prognostic factors for the overall survival, pulmonary metastasis at the first visit (p=0.011), no normalization of tumor markers after induction chemotherapy (p=0.014) and no residual tumor resection irrespective with (p=0.03) or without (p=0.001) normalized tumor makers were significantly poor prognosis in the univariate analysis. On the other hand, patients who underwent residual tumor resection with un-normalized tumor markers (desperation surgery) tended to show a better prognosis compared to previous reports. Conclusion: Although this was an investigation in a rather small group, regardless of the tumor markers normalization, resection of a residual tumor showed the tendency of improving the prognosis of extragonadal germ cell tumor. It was considered that resection of a residual tumor with a high degree of expertise could lead to better treatment outcomes.
Male neoplasms; Germ cells; Embryonal prognosis; Surgery testicular neoplasms
Tsutsumi S, Kobayashi K, Yasui M, Tatenuma T, Noguchi G, Osaka K, et al. Complete Resection of Post- Chemotherapy Residual Tumor Could Improve the Prognosis in Extragonadal Germ Cell Tumor. Clin Surg. 2021; 6: 3220..