Luffarelli P1*, Giorgio G2 , Schiavi MC3 , Ripetti V1 , Ragusa A4 , Pozzi C4 , Casazza C5 and Zullo MA1
1 Department of Pelvic Floor Surgery and Proctology, General Surgery, Campus Bio-Medico University of Rome, Rome, Italy 2 Department of General Surgery, A. Angelucci Hospital ASL RM 5, Subiaco, Rome, Italy 3 Department of Gynecology and Obstetrics, Sandro Pertini Hospital ? La Sapienza University, Rome, Italy 4 Department of Gynecology and Obstetrics, Apuane Hospital, Masa, Italy 5 Pharmacist, Country Manager Biomedix s.r.l., Assago, Milan, ItalyFulltext PDF
Objective: The use of silicon dioxide (POLISORB) causes the elimination of pathogenic germs, promoting the normal formation of intestinal flora (eubiosis) with the insertion of a probiotic. This phenomenon may formulate a new approach to preventing recurrent cystitis. Materials and Methods: This is a multicentric pilot study. All women aged between 18 and 75 and with at least 3 episodes in 1 year or 2 episodes in 6 months of documented bacterial cystitis were enrolled. Polisorb has been administered 2 tps three times a day for 7 days in the first month and 2 tps twice a day for 5 days in the second and third month (1 h between meals and 2 h from taking drugs). Probiotic has been administered 1 tablet twice a day for twenty days a month for 3 months. The effectiveness of the treatment has been assessed considering the reduction in the number of urinary tract infections and the improvement of subjective symptoms. Results: Between September 2018 to July 2019, 45 patients were enrolled in the present study. 17 patients presented UTI at the first urine culture, but only 4 patients showed UTI at the urine culture at three months. 34 patients were completely asymptomatic at the end of the study. No patient experienced side effects and 38 patients were very satisfied about the study protocol. Conclusion: This study confirms that Polisorb is safe and effective for the treatment of UTI and recurrent cystitis.
Enterosorbent; Probiotic; Recurrent cystitis; UTI
Luffarelli P, Giorgio G, Schiavi MC, Ripetti V, Ragusa A, Pozzi C, et al. Pilot Study on the Evaluation of the Effectiveness and Tolerability of an Enterosorbent (POLISORB) Associated with a Probiotic for the Prevention of Recurring Cystitis. Clin Surg. 2020; 5: 2983..