Postoperative Complication after Non-Small Cell Lung Cancer Resection is a Prognostic Factor

Nozomu Motono, Shun Iwai, Aika Funasaki, Atsushi Sekimura, Katsuo Usuda and Hidetaka Uramoto

Department of Thoracic Surgery, Kanazawa Medical University, Japan

^*Correspondance to: Nozomu Motono 

 PDF  Full Text DOI: 10.25107/2474-1647.2493

Abstract

Background: The relationship between the postoperative complication and prognosis in Non-Small Cell Lung Cancer (NSCLC) patients who have undergone surgery has not been elucidated. Methods: Clinical data were analyzed for 549 patients with NSCLC. We divided the patients into preceding period (2009-2013) and late period (2014-2018). Comorbidity was evaluated by the Charlson comorbidity index. The postoperative complication was categorized into five grades according to the Clavien-Dindo classification. Results: Preceding period included 191 patients and late period 358. There were significant differences in differentiation (p<0.01), Ly (p<0.01), pStage (p<0.01), operative procedure (p<0.01) and Clavien-Dindo grade (p<0.01). Because the patient characteristics were significantly different, we adjusted the patient background using propensity score matching. The RFS (p=0.55) and OS (p=0.40) of the propensity score matched patients classified by preceding period and late period were not significant prognostic differences. The RFS of the patients with Clavien-Dindo grade II-IIIb tended to be worse (p=0.06), and the OS was significantly lower than that of 0-I (0.02). Although the Clavien-Dindo grade (HR, 2.61; p=0.01) was identified as significant prognostic factors in the univariate analysis for propensity score matched patients, the Clavien-Dindograde was not significant prognostic factor in the multivariate analysis (HR, 1.60; p=0.25). Conclusion: The severity of postoperative complication classified by the Clavien-Dindo grade might have a prognostic impact on the long-term outcomes in patients who have undergone surgery for NSCLC.

Keywords

Postoperative complication; Clavien-Dindo; Comorbidity; Non-small cell lung cancer; Surgery; Prognosis

Cite the article

Motono N, Iwai S, Funasaki A, Sekimura A, Usuda K, Uramoto H. Postoperative Complication after Non- Small Cell Lung Cancer Resection is a Prognostic Factor. Clin Surg. 2019; 4: 2493..