Wenqin Wang1, Xiang Chen2 and Xiaodong He1*
1Department of General Surgery, Peking Union Medical College, China
2Department of Food and Drug Administration, Wei Fang College Hospital, China
Background: Whether log of odds between the number of positive lymph node and the Number of Negative Lymph Node (LODDS) predict lymph node status and oncological outcomes for Distal Extrahepatic Cholangiocarcinoma (dECA) patients after curative resection remains rarely studied.
Methods: A 743 patients from SEER database between 2004 and 2014 who received curative Pancreatoduodenectomy (PD) were analyzed. We conducted Receiver Operating Characteristic (ROC) curve and univariate (Log-Rank) and multivariate (Cox regression) analysis to identify the diagnostic and prognostic roles of LODDS.
Results: LODDS was the effective variable with the area under the ROC curve (AUC) for prediction of 3-year survival (AUC=0.593) to predict the survival, we determined the optimum cut-off value of LODDS and LODDS<-0.94. In multivariate analysis, LODDS (Hazard Ratio (HR)=0.738, 95% CI 0.574-0.949, P=0.018) was independent prognostic factor for OS.
Conclusion: LODDS was proved to be a good indicator predict for lymph node and survival as an independent indictor for OS in dECA after radical surgical resection.
LODDS; Disease free survival; Distal extrahepatic carcinoma; Pancreatoduodenectomy
Wang W, Chen X, He X. LODDS was a Better Predictor for Lymph Node Status and was a Dependent Poor Prognostic Factor for Distal Extrahepatic Cholangiocarcinoma after Radical Surgical Resection. Clin Surg. 2019; 4: 2446.