Journal Basic Info
- Impact Factor: 1.995**
- H-Index: 8
- ISSN: 2474-1647
- DOI: 10.25107/2474-1647
Major Scope
- Pediatric Surgery
- Minimally Invasive Surgery
- Cardiovascular Surgery
- Bariatric Surgery
- Emergency Surgery
- Oral and Maxillofacial Surgery
- Thoracic Surgery
- Endocrine Surgery
Abstract
Citation: Clin Surg. 2018;3(1):2152.Research Article | Open Access
Preoperative Platelet to Lymphocyte Ratio Predicts Early Postoperative Relapses in Patients with Stage II Colon Cancer
Takashi Okuyama, Shunya Miyazaki, Shinichi Sameshima, Emiko Takeshita, Takashi Mitsui, Yuko Ono, Tamaki Noie and Masatoshi Oya
Department of Surgery, Dokkyo Medical University, Japan
Department of Pathology, Dokkyo Medical University, Japan
*Correspondance to: Takashi Okuyama
PDF Full Text DOI: 10.25107/2474-1647.2152
Abstract
Background: Its predictive utility in patients with stage II colon cancer undergoing curative resection is yet to be fully evaluated. The purpose of this study was to evaluate its utility as a predictive maker of preoperative PLR on postoperative relapse in patients with stage II colon cancer.Methods: A total 154 patients with stage II colon cancer who had undergone curative resection between 2007 to 2016 were eligible for this study. The present study retrospectively analyzed the data of these patients from a single hospital. Receiver Operator Characteristic (ROC) curve was applied to determine the most significant cutoff vale of PLR. Kaplan-Meier curve and Cox proportional models were used to compare high and low PLR groups and to identify the risk factor for relapse.Results: The median PLR was significantly higher in patients who had developed tumor recurrence than in those who did not (p=0.04). Using receiver-operator characteristics curve analysis, the optimal cutoff value of PLR for the discrimination between patients who had relapse and those who did not was 198. Tumor relapses occurred significantly more frequent in patients with high PLR than compared in those with low PLR (p=0.001). Patients with low PLR were significantly better RFS than those with high PLR (95% CI 74.9-107.5, p<0.001). High PLR was an independent risk factor for RFS in multivariate analysis (HR=4.32, 95% CI=1.58-11.79, p=0.004).Conclusion: In this study, PLR was suggested as a useful predictive marker for postoperative relapse in patients with stage II colon cancer.
Keywords
Cite the article
Okuyama T, Miyazaki S, Sameshima S, Takeshita E, Mitsui T, Ono Y, et al. Preoperative Platelet to Lymphocyte Ratio Predicts Early Postoperative Relapses in Patients with Stage II Colon Cancer. Clin Surg. 2018; 3: 2152.