Ewa Bieniek1*, Karolina Skołucka-Szary2, Andrzej Lewiński1,3 and Sylwester Piaskowski2
1Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital – Research Institute,Poland
2Celther Polska Sp. z o.o. Inwestycyjna 7, Poland
3Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Poland
The aim of this study was to evaluate the efficacy of the DibuCell Active dressing, the fully biodegradable dressing based on dibutyrylchitin, in the treatment of venous ulcers. The dressing undergoes full degradation within the wound. It does not require to be replaced (what significantly reduces the traumatization of newly formed tissues) and the only thing that is needed is to add yet another layer of the dressing once the previous one has been degraded. Evaluation of the effectiveness of the dressing was performed based on the analysis of results obtained during the prospective, multicentre, randomized, single-blinded clinical trial ULCERUS 1/2014. Statistical analysis was performed using data obtained from 137 patients. The control group was treated with the Biatain Ag dressing, while the study group with both the DibuCell Active and Biatain Ag dressings. In the control group, 38.24% of ulcers were healed, while in the study group ‒ 34.78%. Comparing only the subset of normotensive patients, the study showed statistically significant differences (p<0.05) in the rate of ulcer healing process between these two groups. The rate of the healing process of ulcers was higher in the group of patients treated with the DibuCell Active and Biatain Ag dressings compared to patients treated only with the Biatain Ag dressing. Adding the investigated dressing to standard therapy results in beneficial acceleration of the healing process. Addition of the DibuCell Active dressing to standard therapy seems to improve the treatment efficacy, especially in the case of large and extensive ulcers.
Biodegradable dressings; Chitin dibutyrate; Chronic venous insufficiency; Venous ulcers
Bieniek E, Sko?ucka-Szary K, Lewi?ski A, Piaskowski S. Leg Ulcer Treatment using an Innovative Biodegradable Dressing not Requiring Replacements. Clin Surg. 2018; 3: 2071.