Clin Surg | Volume 3, Issue 1 | Research Article | Open Access

Effect of Prophylactic Transcatheter Arterial Chemoembolizationon the Recurrence Rate of Hepatocellular Carcinoma with Microvascular Invasion after R0 Resection

Ke-Yue Li*, Shuai-min Zhang, Cheng-Xian Shi, Ke-li Tang and Jian-zhao Huang

Department of Hepatobiliary Surgery, Guizhou Provincial People’s Hospital, China

*Correspondance to: Ke-Yue Li 

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Abstract

Objective: We investigated the effect of preventive Transcatheter Arterial Chemoembolization (TACE) in preventing recurrence of Hepatocellular Carcinoma (HCC) after R0 resection.Methods: We retrospectively analyzed recurrence rates over time for 250 cases of HCC after R0 resection, who were divided into patients who underwent TACE (TACE+) and had Microvascular Invasion(MVI+; n=80); TACE+ but did not have MVI (MIV-; n=100); MVI+ but did not undergo TACE (TACE-, n=30); or TACE-/MVI- (n=40).Results: Among both TACE+ and TACE- patients, MVI- patients had significantly lower recurrence rates at 2(29/100, 29% and 15/40, 37.5%) and 3(40/100, 40.0% and 21/40, 52.5%) years after their procedures than did MVI+ patients (35/80, 43.8% and 20/30, 66.7%; 44/80, 55% and 23/30, 76.7%); the TACE- patients also had lower recurrence rates in the 1st year (9/40, 22.5% vs. 14/30, 46.7%), (all P<0.05). Among MVI+ patients, the TACE+ group had significantly lower recurrence rates at 1(20/80, 25.0%), 2(35/80, 43.8%) and 3(44/80, 55.0%) years than the TACE- group (14/30, 46.7% and 20/30, 66.7% and 23/30, 76.7%), (all P<0.05). Recurrence rates in the MVI-patients tended to be lower at 1(20/100, 20.0%), 2(29/100, 29.0%) and 3(40/100, 40.0%) years for the TACE+ group (9/40, 22.5% and 15/40, 37.5% and 21/40, 52.5%), but not significantly so (all P>0.05).Conclusion: Recurrence rates for MVI+ patients were significantly higher than for MVI- patients. Postoperative adjuvant TACE may be beneficial for HCC patients with MVI.

Keywords:

Hepatocellular carcinoma; Transcatheter arterial chemoembolization; Microvascular invasion; R0 resection; Recurrence

Citation:

Li K-Y, Zhang S-M, Shi C-X, Tang K-l, Huang J-Z. Effect of Prophylactic Transcatheter Arterial Chemoembolizationon the Recurrence Rate of Hepatocellular Carcinoma with Microvascular Invasion after R0 Resection. Clin Surg. 2018; 3: 2059.

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