Mean Red Cell and Platelet Volume and Blood Cells Aggregation in Children with Inflammatory Bowel Diseases

Grigory Ya Levin, Alexandra N Popovicheva, Larisa N Sosnina, El’vira N Fedulova and Yury A Sheremet’ev

Department of Gravitation Surgery and Hemodialysis, Federal State Budgetary Institution of the Ministry of Health of Russian Federation, Russia

^*Correspondance to: Levin Grigory Yakovlevich 

 PDF  Full Text DOI: 10.25107/2474-1647.2049

Abstract

Background: It has been discussed in literature whether platelet and erythrocyte indexes can serve as biomarkers of activity of Inflammatory Bowel Diseases (IBD). However, how these indexes influence functional properties of platelets and erythrocytes, primarily their aggregation capacity in children with IBD, remains unclear.Objectives: The objective of the present research was to study the association between the changes in platelet and erythrocyte indexes (MPV, PDW, MCV, and RDW) blood cells aggregation during the course of therapy of children with IBD.Methods: The study included 50 patients of both sex ages 6 to 17, 25 patients with UC, and 25 patients with CD. The diagnosis was based on a complex examination including endoscopic examination of the intestinal mucosa with a morphological analysis of biopsies. Spontaneous (shear-induced) aggregation of platelets and erythrocytes was studied using a rheoscope designed according to the method.Results: It was shown that the mean platelet volume and the Platelet Distribution Width (PDW) significantly decrease at IBD, whilst Erythrocyte Distribution Width (RDW) and mean erythrocyte volume increase. A strong correlation between RDW and IBD severity as well as a negative correlation between MPV and IBD severity were revealed. For the first time it has been established that, with a reduced volume, platelets and erythrocytes retain their functional properties, in particular their aggregation activity.Conclusion: Important reason for microcirculation disorder during IBD is the increase in platelet and erythrocyte aggregation, accompanied by the decrease in their volume and increase in erythrocyte anisocytosis.

Keywords

Erythrocyte and platelet indices; Erythrocyte and platelet aggregation; IBD

Cite the article

Levin GY, Popovicheva AN, Sosnina LN, Fedulova EN , Sheremet�ev YA. Mean Red Cell and Platelet Volume and Blood Cells Aggregation in Children with Inflammatory Bowel Diseases. Clin Surg. 2018; 3: 2049.